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For Professionals
Characteristics of Lynch Syndrome
Diagnosis and Management
Diagnostic Guidelines
Diagnostic Tools for Professionals
Recommended Screening Guidelines
Genetic Counselors and Laboratories
Specific Mutated Genes
Other Genetic Cancers
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"If you don't ask the right questions, you do not get the right answers. A question asked in the right way often points to its own answer. Asking questions is the A-B-C of diagnosis. Only the inquiring mind solves problems.

-Edward Hodnett (1841-1920)





Diagnostic Identification Tools: Essential and effective tools available to medical professionals to calculate the risk for Lynch syndrome.  These tools are recommended by NCCN Guidelines 1/2014.  "Consider testing individuals with >5% risk of LS on any mutation prediction model MMR Pro, PREMM 1,2,6 MMR Predict."


PREMM Prediction Model for MLH1, MSH2 and MSH6 - An easy qustionaire clinical prediction designed to determine the clinical probability of an individual carrying a mutation of the basic Lynch cancers.

MMR Pro- This assessment device developed by Johns Hopkins researchers allows medical health professionals and families to make decisions about cancer prevention screenings and calculates the risk of an individual carrying a gene defect. It alleviates the time necessary to assess a family history and is stated to accurately identify more at risk individuals. Download page and Tool Information. Other tools for genetic risk are also available upon this page.


Reviewed 4/10/2014


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