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Page 8 of 9
LYNCH SYNDROME MUTATED GENES
Lynch syndrome cancers are caused by mutations in seven mismatch repair genes, specifically:
MSH2 2p16 chromosome 45-50%
MLH1 3p22.3/A> chromosome 20%
MSH6 2p16 chromosome 10%
PMS2 7P22.1 chromosome 1%
PMS1 2Q32.2 chromosome Rare
MSH3 5q14.1 chromosome Rare
EXO1 1q1q43 chromosome Rare
Other Genes Not Yet Discovered 20-25% prev